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Prescription Healthcare Products
APR TD011 – Epidermolysis Bullosa

Holding website  

  • About Us
    • What we do
      • Strategic Approach
    • Management Team
    • Collaboration & Partnering
    • Investors
    • Careers
      • Open Positions
        • Head of Medical Affairs
    • Privacy
  • APR Products
    • Prescription Healthcare Products
      • PKU GOLIKE® Family
      • Nexodyn® – Advanced Wound Care
        • Tehclo Technology
      • Diclofenac Immediate Release
        • Immediate Release Technology
        • Diclofenac 50 mg products
      • Ondansetron ODF
        • ODF Technology
        • Ondansetron ODF products
      • APR TD011 – Epidermolysis Bullosa
        • Tehclo Technology
      • APR TD012 – Hailey Hailey Disease
        • Tehclo Technology
      • APR 1204 – Ocular Surface Diseases
        • Tehclo Technology
      • Exelya®
        • Exelya®
        • Tehclo Technology
    • Consumer Healthcare Products
      • Acute Pain
        • Diclofenac 25 mg products
      • Healthy Aging – SwitzAge™
      • Pediatric
        • Halykoo
    • Therapeutical Areas
      • Inherited Metabolic Disorders
        • What is PKU (Phenylketonuria)?
      • Advanced Wound Care
        • Unmet Medical Need
      • Cancer Supportive Care
        • Nausea and vomiting
        • Oncodermatology
      • CNS (migraine)
      • Rare Dermatological Diseases
        • Epidermolysis Bullosa
        • Hailey Hailey Disease
      • Eye laser surgery
    • Pipeline
  • Our Services
    • Solid Dosage Forms
      • Oral Pharmaceuticals
        • Integrated project development
        • Project design planning
      • Oral Nutraceuticals
        • Integrated project development
        • Project design planning
      • Oral Medical Devices
        • Integrated project development
        • Project design planning
    • Non-Solid Dosage Forms
      • Topical Pharmaceuticals
        • Integrated project development
        • Project design planning
      • Topical Dermocosmetics
        • Integrated project development
        • Project design planning
      • Topical Medical Devices
        • Integrated project development
        • Project design planning
    • Analytical Services
    • Certifications
  • Media
    • Presentations
    • Press Releases
  • Contacts
    • Location
    • Vigilance
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APR TD011
EPIDERMOLYSIS BULLOSA

APR TD011 is a clinical stage drug candidate for the treatment of blisters and wounds in EB patients.
The product thanks to its chemical-physical unique properties is expected to:
  • Reduce the bioburden allowing both prevention of the infection and ensure an antibioticsparing approach with no bacterial resistance.
  • Reduce the skin inflammation, which is highly linked with skin cancer and death.
  • Support a faster healing and allow a reduction risk of scar.
The proposed benefits are expected to be achieved thanks to the peculiar properties of the solution:
  • Control the bioburden: based on data generated so far it can be postulated that the presence of HClO, a well-known antimicrobial agent, could support a reduction of bioburden, as well as the unique pH/(Oxidation reduction potential) ORP create conditions unfavorable to bacterial growth.
  • Modulation of metallo-proteases (MMPs): the low pH of the product can decrease the activity of the alkaline-pH-dependent of metalloproteases (MMPs), which are the main triggers for inflammation process. High ORP values may also be involved in the inhibition of MMPs activity.
  • Modulation of inflammation mediators: molecular analysis shows APR TD011 to be able to modulate several inflammatory pathways.
  • Tissue regeneration properties: multi-level activity of APR TD011 could lead to an optimal conditions for new cells growth, thus supporting the physiological wound healing process.

TEHCLO® TECHNOLOGY

Tehclo™ is the globally patented nanotechnology platform applied to the production of unique hypochlorous acid solutions that ensures the most consistent quality for best-in-class clinical outcomes.

The nanotechnology applied drives electrolysis using a current several times stronger than other standard electrolysis process, minimizing chloride requirements and producing acid oxidizing solution with >95% hypochlorous acid (HClO) purity and 0% hypochlorite (OCl-) as well as the lowest pH range (2.5-3.0) and high ORP (>1100 mv).

Ondansetron ODF APR TD012 – Hailey Hailey Disease
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